What is Orthovisc​ and How Does It Work

Medical professionals constantly seek efficient solutions for osteoarthritis, a progressive joint disorder affecting millions worldwide, most commonly in the knee. For patients who are not ready for surgical intervention, viscosupplementation offers an effective, non-invasive option, and ORTHOVISC injections present a perfect solution in this scenario. Whether you are a healthcare professional or a patient suffering from osteoarthritis, this article will help you understand what ORTHOVISC is, how it is used, and how it can help alleviate the discomfort and pain caused by this condition. 

What is Orthovisc?

Orthovisc is a sterile, high molecular weight hyaluronic acid (HA) solution used for intra-articular injection, primarily in the knee joint. Unlike earlier HA products derived from animal sources such as rooster combs, ORTHOVISC is made through bacterial fermentation, eliminating animal proteins and reducing the risk of allergic reactions.

ORTHOVISC is indicated for patients with knee osteoarthritis who have not responded adequately to conservative treatments such as physical therapy, weight management, or oral analgesics. ORTHOVISC knee injections are categorised as viscosupplementation therapies, designed to replenish the synovial fluid that lubricates and cushions the joints.

How Does Orthovisc Work?

The joints in the human body are protected by synovial fluid, which contains hyaluronic acid as a key component. This fluid acts both as a lubricant and a shock absorber, allowing smooth, pain-free movement. In patients with osteoarthritis, the quantity and quality of HA in the synovial fluid decline, resulting in decreased joint lubrication, increased friction, and the progression of symptoms such as stiffness and pain.

ORTHOVISC works by restoring the viscoelasticity of the synovial fluid. When injected into the joint space, it supplements the natural HA, providing immediate mechanical benefits and helping to reduce inflammation. Its high molecular weight mimics the natural viscosity of healthy synovial fluid, bringing the following advantages:

• Enhancing shock absorption during strenuous activities
• Improving lubrication to reduce joint friction
• Supporting smoother joint articulation
• Reducing inflammatory responses in the joint

Although ORTHOVISC does not entirely regenerate cartilage or stop the progression of osteoarthritis, it helps manage symptoms and delay the need for more invasive procedures like total knee replacement.

Treatment Protocol

ORTHOVISC should be administered by a trained medical professional in a series of three intra-articular injections given at weekly intervals. The treatment is usually performed in a clinical setting.

Proper administration steps:

• Thoroughly clean and disinfect the area around the injection site. 
• Apply a local anaesthetic if needed. 
• The injection is placed directly into the synovial cavity of the knee.
• The entire procedure takes only a few minutes, and patients can resume most daily activities within 24 to 48 hours.

Most patients report minimal discomfort during the procedure. However, they are generally advised to avoid strenuous activities such as running or heavy lifting for at least 48 hours after the injection.

Expected Results

Patients typically feel relief from osteoarthritis symptoms after the second or third injection. Some patients experience improvement sooner, while for others, the therapeutic benefits may take a few weeks to become evident.

Clinical studies have shown that pain relief from ORTHOVISC treatment can last up to six months or longer, depending on individual factors such as activity level, severity of osteoarthritis, and overall joint health.

Patients often report the following improvements:

• Reduced knee pain during movement
• Decreased stiffness, especially in the morning or after periods of inactivity
• Enhanced mobility and ability to perform daily tasks
• Improved participation in low-impact physical activities like walking or swimming

Since the effects of the injections are temporary, patients can repeat the treatment at intervals determined by their healthcare provider.

Who Is a Good Candidate for Orthovisc?

ORTHOVISC is intended for patients with mild to moderate knee osteoarthritis who:

• Have not achieved adequate relief from first-line treatments such as non-steroidal anti-inflammatory drugs (NSAIDS) or corticosteroid injections
• Wish to delay knee replacement surgery
• Are not suitable candidates for surgery due to age, comorbidities, or personal preference

On top of that, because ORTHOVISC is not derived from animal sources, it is especially beneficial for individuals who are allergic to avian proteins. This is the key difference when it comes to the debate known as ORTHOVISC vs Synvisc​ – another injectable treatment which is made from chicken combs. 

Contraindications

Although ORTHOVISC is well-tolerated by most patients, it is not recommended for:

• Individuals with active joint infection or skin disease at the injection site
• Patients with known hypersensitivity to hyaluronan products
• Individuals who suffer from severe joint instability that may compromise injection efficacy

A thorough medical history and examination should be conducted before initiating treatment to ensure suitability and minimise risks.

Potential Side Effects

Because ORTHOVISC is administered locally, serious side effects are rare. The most commonly reported adverse reactions are mild and include:

• Swelling or pain at the injection site
• Temporary stiffness or warmth in the knee joint
• Bruising or redness near the injection area

These effects typically resolve on their own within a few days. Serious complications, such as joint infection or allergic reaction, are rare when proper sterile technique is used.

It is essential for medical professionals to educate patients about post-treatment care to ensure optimal outcomes and minimise discomfort. They should also encourage patients to report any persistent or unusual symptoms to their healthcare provider as soon as possible.

Clinical Evidence and Safety Profile

Numerous clinical trials and post-market studies have validated the efficacy and safety of ORTHOVISC in treating knee osteoarthritis. According to data submitted to the FDA, ORTHOVISC demonstrated statistically significant improvements in pain and function compared to placebo.

Its high molecular weight formulation provides prolonged joint residence time, contributing to sustained symptom relief. Repeat treatment cycles have been shown to maintain or enhance benefits without increasing adverse effects.

Conclusion

ORTHOVISC® is a clinically proven treatment for managing knee osteoarthritis symptoms in patients who have not responded to conventional therapies. Its high molecular weight, non-animal-derived hyaluronic acid formulation allows it to safely and effectively supplement the synovial fluid, providing significant relief from pain and improving joint function. Orthopaedic specialists and other healthcare professionals wishing to provide their patients with an effective non-surgical treatment can buy Orthovisc at the Best Buy Fillers online store.

References: 

Pereira TV, Jüni P, Saadat P, et al. Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis. BMJ. Published online July 6, 2022:e069722.

Legré-Boyer V. Viscosupplementation: Techniques, indications, results. Orthopaedics & Traumatology: Surgery & Research. 2015;101(1, Supplement):S101-S108.

Park J, Hue Jung Park, Min Cheol Rho, Joo J. Viscosupplementation in the Therapy for Osteoarthritic Knee. Applied Sciences. 2021;11(24):11621-11621.