Under Eye Profhilo Gone Wrong: What Can Happen and How to Fix It

Key Takeaways
- Profhilo is not officially licensed for under-eye use, making treatment in this area more prone to complications.
- Common issues include swelling, lumps, Tyndall effect, and uneven texture.
- Choosing the wrong injection depth or technique increases the likelihood of visible complications.
- Most issues can be managed or corrected with prompt intervention.
- Patient education and injector training are essential for minimising risk.
Profhilo is widely praised for its ability to hydrate and firm the skin without adding volume like traditional dermal fillers. But while its results on the face, neck, and décolletage are often outstanding, using Profhilo under the eyes remains an off-label procedure with unique challenges.
Despite increasing popularity, under-eye treatments with Profhilo require specific anatomical understanding and injector expertise. If not performed correctly, they can lead to unwanted outcomes, some of which may take weeks or months to resolve.
Practitioners looking to expand their aesthetic offerings can buy Profhilo fillers from licensed distributors, such as Best Buy Fillers online store, but only after mastering the nuances of advanced injection zones like the tear trough.
Is Profhilo Safe for Under-Eye Use?
Technically, Profhilo is not licensed for under-eye injections, meaning that any treatment in this area is considered off-label. However, many experienced injectors report successful outcomes when following correct protocols. The key lies in precise technique, understanding the delicate anatomy of the tear trough, and thoroughly assessing each patient’s suitability.
Although Profhilo is less viscous than traditional fillers, its high spreadability can be a double-edged sword under thin periorbital skin. Profhilo before and after eyes results may vary, as the product can sometimes migrate or settle unevenly, leading to noticeable side effects in certain patients.

Possible Risks and Complications to Watch for
Complications from under-eye Profhilo treatment can occur due to several technical, anatomical, or patient-related reasons. Practitioners and patients need to be aware of what may go wrong when using Profhilo in such a delicate area.
The most frequently reported Profhilo under eye complications include:
- Persistent puffiness or swelling, often due to product migration or superficial placement.
- Lumpiness or nodules, sometimes visible under the skin.
- Tyndall effect, where light reflects off superficial HA deposits, creating a bluish tint.
- Asymmetry or textural irregularities, if injected unevenly.
- Infection or inflammation, though rare, especially if aftercare instructions are not followed.
- Delayed onset swelling, which may develop days after the injection due to immune response or product migration.
- Allergic reactions, although very uncommon, can present as redness, itching, or prolonged swelling.
- Vascular compromise, a rare but serious risk if the product is accidentally injected into or compresses a blood vessel.
- Under-correction or no visible improvement, particularly in patients with severe hollowness or skin laxity.
Proper patient selection and technique are crucial to reducing these risks.
Why These Side Effects Occur
The most common reason for complications is improper product placement or volume misjudgment. Injecting too superficially or using too much product increases the risk of visibility and migration in the thin under-eye tissue.
Most cases of under eye swelling after Profhilo are caused by either improper injection depth or injecting too much product too quickly. The under-eye area lacks the same subcutaneous fat found in other regions, which means even small errors in technique can result in visible issues.
Additionally, the skin in the periorbital area is much thinner and more prone to showing fluid accumulation or product irregularities. Migratory behaviour of Profhilo due to its high spreadability may also cause it to settle in unintended areas.
Managing and Correcting Profhilo Complications
Experiencing complications from under-eye Profhilo is distressing, but most issues can be improved or reversed with the right corrective steps. If you’ve experienced under eye Profhilo gone wrong, the first step is a professional assessment.
Management options include:
- Massage and lymphatic drainage, often helpful for minor swelling or unevenness.
- Hyaluronidase (off-label), although Profhilo’s low cross-linking makes it less responsive than traditional fillers.
- Topical anti-inflammatory creams to reduce mild irritation or puffiness.
- Laser or RF treatments, in cases of persistent lumps or scarring.
For injectors, knowing how to fix Profhilo lumps promptly can make a significant difference in outcome and patient satisfaction.
How Practitioners Can Prevent Under-Eye Issues
Advanced training and conservative dosing are key to safe under-eye use. Awareness of the Tyndall effect Profhilo risk and other possible side effects is crucial to minimise complications:
- Use a microbolus or microdroplet technique with minimal product.
- Avoid direct injection into the tear trough if the patient has thin or hollowed skin.
- Choose candidates with minimal skin laxity and good hydration.
- Inject slowly and deeply enough to prevent superficial pooling.
Guidelines for Patients: What to Do After Treatment
Patients undergoing under-eye Profhilo should follow tailored aftercare, similar to other periorbital treatments. According to best practice and clinical case results:
- Apply a cold compress within the first 24 hours to reduce swelling.
- Avoid makeup, saunas, and vigorous exercise for 48 hours post-treatment.
- Report any unusual swelling, pain, or skin discolouration to the clinic immediately.
- Follow up with your injector if lumps, puffiness, or asymmetry persist beyond two weeks.
A well-informed patient is less likely to panic and more likely to participate in a positive treatment outcome.

FAQ
How can Profhilo go wrong?
Profhilo can cause complications if injected superficially, too quickly, or in excessive amounts. This may result in swelling, lumps, or the Tyndall effect.
What happens if Profhilo is injected too deep?
Injecting Profhilo too deeply can reduce its effectiveness, and in rare cases, lead to unintended spread or poor aesthetic outcome.
Does Profhilo make you look older?
Inappropriate application, especially under the eyes, may exaggerate puffiness or skin texture, creating an aged appearance. When done correctly, however, Profhilo generally rejuvenates the skin.
Can Profhilo be injected incorrectly?
Yes, improper technique or poor patient selection can result in uneven results, complications, or dissatisfaction with the outcome.
Is anything better than Profhilo?
When considering long-term collagen stimulation and volumising benefits, some patients and practitioners compare Sculptra vs Profhilo. While Profhilo focuses on hydration and skin quality, Sculptra promotes gradual volume restoration and collagen production.
Finally
Profhilo is an excellent skin hydrator and bio-remodeller, but the under-eye area remains a high-risk zone due to anatomical sensitivity. When used with caution and expert technique, it can yield beautiful results.
However, both patients and practitioners must understand the potential pitfalls of under eye Profhilo gone wrong and know how to act quickly if problems arise. Proper training, product knowledge, and patient education form the foundation of successful outcomes.
Sources:
- Cassuto, D.; et al. Safety Assessment of High- And Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. ResearchGate. 2020. https://www.researchgate.net/publication/342389775_Safety_Assessment_of_High-_and_Low-Molecular-Weight_Hyaluronans_ProfhiloR_as_Derived_from_Worldwide_Postmarketing_Data
- Diwan, Z.; et al. A Prospective Study on Safety, Complications and Satisfaction Analysis for Tear Trough Rejuvenation Using Hyaluronic Acid Dermal Fillers. PMC. 2020. https://pmc.ncbi.nlm.nih.gov/articles/PMC7209844/
- Urdiales-Gálvez, F. and Farollch-Prats, L. Management of Tear Trough with Hyaluronic Acid Fillers: A Clinical-Practice Dual Approach. PMC. 2021. https://pmc.ncbi.nlm.nih.gov/articles/PMC8127324/
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