Sunekos vs Profhilo: Key Differences Explained

Key Takeaways

• Profhilo and Sunekos are both injectable skin treatments but differ in composition, function, and target results.
• Profhilo uses high-concentration pure hyaluronic acid to deeply hydrate and remodel the skin.
• Sunekos combines hyaluronic acid with amino acids to support the extracellular matrix and stimulate fibroblasts.
• Profhilo works best for skin laxity and overall firmness, while Sunekos targets early ageing signs and fine lines.
• Treatment protocols, injection techniques, and outcomes differ – practitioners must assess patient skin needs.
• Both treatments can be used on the face, neck, hands, and décolleté.
• In some cases, Profhilo and Sunekos can be layered or alternated, depending on clinical goals.

When comparing which is better Profhilo or Sunekos, it’s essential to understand that both products serve different clinical purposes despite falling under the skin booster umbrella. These two treatments are popular among patients seeking non-surgical facial rejuvenation, but they differ significantly in ingredients, mechanisms, and expected outcomes. 

Here is a Sunekos vs Profhilo comparison that can help medical professionals decide the right treatment for their patients.

Profhilo and Sunekos: A Product Overview

Profhilo is a bioremodeling injectable developed by IBSA Derma. It contains one of the highest concentrations of pure hyaluronic acid (HA) on the market and aims to improve skin laxity, texture, and hydration from within. 

Sunekos, manufactured by Professional Dietetics, is classified as a biorevitalisation treatment. It blends HA with a patented mix of amino acids, designed to regenerate the skin’s extracellular matrix (ECM), promote fibroblast activity, and support collagen and elastin synthesis.

Comparing Key Ingredients

The main difference between Sunekos and Profhilo lies in their formulation. Profhilo contains 64mg of high- and low-molecular-weight HA without cross-linking agents. Its unique composition enables it to spread evenly and stimulate tissue hydration and remodelling. 

On the other hand, Sunekos ingredients vs Profhilo show a distinct approach. Sunekos incorporates HA in lower concentrations (3mg/ml) along with amino acids like glycine, proline, leucine, and lysine to promote ECM regeneration and enhance skin metabolism.

How Each Treatment Works

Understanding how each injectable functions can help practitioners set realistic expectations and optimise treatment outcomes. Though both support skin rejuvenation, Profhilo and Sunekos use different biological approaches.

Profhilo:

• Acts as a deep tissue hydrator and bio-stimulator through slow-release pure HA technology that spreads evenly across the dermis.
• Stimulates the production of collagen types I, III, IV, and VII and elastin, improving skin elasticity, firmness, and texture.

Sunekos:

• Promotes fibroblast activity through a patented combination of HA and amino acids to regenerate the extracellular matrix (ECM).
• Encourages collagen and elastin production while supporting tissue repair, making it especially effective for early signs of ageing and delicate areas.

Treatment Protocols and Techniques

Profhilo is typically administered using the BAP (Bio Aesthetic Points) technique, requiring five injection sites per facial side. A standard protocol includes two sessions spaced four weeks apart. This approach is especially effective for difficult areas such as the profhilo under eyes. 

Sunekos protocols differ depending on the product variant (Sunekos 200, Sunekos 1200, etc.). Most protocols consist of 3 to 4 sessions spaced 7 to 10 days apart. The product is injected intradermally in microboluses or linear threads across targeted zones.

Expected Results and Treatment Areas

Profhilo results become visible within 4 to 8 weeks, showing improved elasticity, hydration, and lifting effects. The treatment is particularly effective in the lower face, cheeks, and neck. Results on the profhilo neck before and after images show smoother, more hydrated skin with visible lifting. 

Sunekos results include improved skin tone, reduced fine lines, and enhanced texture. The treatment is effective around the eyes, forehead, neck, and even on the hands. The longevity of results varies depending on the variant used and the patient’s skin condition.

Choosing the Right Patient Profile

Selecting the appropriate treatment depends on a patient’s skin condition, age, lifestyle, and rejuvenation goals. While both Profhilo and Sunekos deliver skin-boosting benefits, they are optimally suited to different profiles. Aesthetic practitioners should consider these distinctions when tailoring a personalised treatment plan.

Profhilo:

• Best suited for patients aged 35+ who present with mild to moderate skin laxity, dullness, and early signs of sagging.
• Ideal for those seeking an all-over rejuvenation effect and improvement in skin firmness and hydration.
• Appropriate for patients who want a low-maintenance protocol with fewer sessions.
• Beneficial for individuals with thinning or ageing skin in areas like the lower face, neck, and décolleté.

Sunekos:

• Recommended for younger patients (30+) with early signs of ageing or delicate skin concerns.
• Particularly effective for those with dark circles, crepey skin texture, or needing subtle volume restoration under the eyes.
• Suitable for patients who prefer more gradual results with a gentler approach to collagen stimulation.
• Ideal for treating finer lines and promoting ECM regeneration in thinner, more sensitive skin types.

Can Profhilo and Sunekos Be Combined?

Yes. Combining Profhilo and Sunekos is clinically possible, though it requires careful planning. Alternating them in different treatment phases or targeting different areas with each product can yield synergistic effects. 

For instance, Sunekos may be used in the periocular region while Profhilo treats the cheeks and jawline. Avoiding overlapping sessions is important, as both treatments stimulate collagen differently and require time to take effect.

Selecting the Optimal Treatment Plan

Choosing between Profhilo and Sunekos depends on the patient’s age, skin type, aesthetic goals, and specific concerns. Practitioners should assess the degree of skin laxity, photoaging, and hydration levels before deciding. In many cases, a tailored combination approach or a phased treatment plan starting with Sunekos and followed by Profhilo may provide balanced rejuvenation outcomes. 

It is also important to consider patient preference regarding treatment frequency, downtime, and budget. Additionally, understanding the biological response each product elicits can guide optimal sequencing and long-term planning.

FAQ

Can you have Sunekos and Profhilo together?

Yes, but not in the same session. Combining them through an alternating treatment plan may offer enhanced results across multiple skin layers.

Does Sunekos tighten skin?

Yes, it improves skin firmness by regenerating the ECM and boosting elastin production. This makes it particularly effective in managing fine lines and mild laxity.

Does Profhilo increase collagen?

Absolutely. It promotes natural collagen and elastin synthesis, improving skin density and resilience over time.

How long does Profhilo last?

Results typically last around six months, depending on lifestyle and skin condition. Most patients benefit from two maintenance sessions per year.

How long does Sunekos last for?

Sunekos results generally last 4 to 6 months, varying by patient age and skin status. Regular maintenance every few months can help sustain the benefits.

In Conclusion

The decision between Profhilo and Sunekos should not be based on popularity alone but on clinical evaluation of the patient’s unique needs. While both products offer skin-enhancing benefits, their mechanisms, protocols, and ideal use cases differ significantly. To achieve optimal results, aesthetic practitioners should understand the nuances of each and design bespoke treatment plans. 

For practitioners looking to integrate Profhilo and Sunekos into their offering, you can buy Profhilo wholesale and Sunekos products from trusted distributors to ensure product authenticity and quality.

Sources:

1. Cassuto, D.; et al. Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. PMC. 2020. https://pmc.ncbi.nlm.nih.gov/articles/PMC7327616/
2. Liu, Y.; et al. Facial Rejuvenation: A Global Trend of Dermatological Procedures in the Last Decade. PMC. 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11150033/
3. Ayse Gul Kabakci; et al. Assessing the Rejuvenation Effectiveness of a Hyaluronic Acid and Amino Acid Mixture in the Periorbital Region. PMC. 2023. https://pmc.ncbi.nlm.nih.gov/articles/PMC10084865/