From Face to Neck: Complete Guide to Profhilo Injection Points

Key Takeaways

• Profhilo is a stabilized hyaluronic acid (HA) skin bioremodeling treatment that hydrates and firms the skin without adding volume.
• The BAP technique targets 5 strategic Profhilo injection points on each side of the face to maximize even distribution and safety.
• Neck injection points differ from the face and address crepey skin and laxity with a modified technique.
• Patients typically need two sessions spaced four weeks apart, followed by maintenance every 6–9 months.
• Profhilo is ideal for patients with early signs of aging, and it can be combined with other treatments when timed properly.

What Is Profhilo?

Profhilo is a cutting-edge skin bioremodeling treatment made from stabilized, high-purity hyaluronic acid. Unlike traditional fillers, it doesn’t add volume or restrict muscle movement. Instead, it spreads smoothly under the skin to deeply hydrate tissue, stimulate collagen and elastin production, and improve skin tone and elasticity.

With 64mg of HA in a 2ml syringe, Profhilo contains one of the highest concentrations of hyaluronic acid on the market. Patients report visible improvements in skin texture, radiance, and firmness, especially on the face and neck. We wrote in detail about what is Profhilo on our blog so interested medical professionals can learn more.  

Clinics and licensed professionals can buy Profhilo online at Best Buy Fillers, a trusted supplier of authentic aesthetic products.

Profhilo Injection Points for the Face: The BAP Technique

The Bio Aesthetic Points (BAP) technique is the standardized approach used to administer Profhilo to the face. This method involves injecting into five specific anatomical landmarks on each side, selected for their:

• Optimal HA diffusion properties
• Minimal vascular and nerve structures
• Ability to cover the mid and lower face effectively

BAP Injection Points (Each Side):

• Zygomatic Protrusion (cheekbone)
• Nasal base (near the nostril)
• Tragus level (preauricular area)
• Chin (mental crease)
• Mandibular angle (jawline)

Each point receives 0.2ml of Profhilo, deposited at the deep dermis or just above the SMAS layer. The technique minimizes risks of bruising and vascular compromise, making it both safe and effective.

Profhilo Injection Points for the Neck

The Profhilo face and neck treatment has become increasingly popular, particularly for patients struggling with neck crepiness and sagging.

Neck Injection Technique:

• Typically involves 10 injection points (5 on each side)
• Points are spaced evenly in a grid pattern across the anterior neck
• Injections are placed in the superficial subcutaneous layer, slightly more superficial than facial injections

Key Differences from Facial BAP Technique:

• Skin thickness is less on the neck, requiring more superficial placement
• Distribution pattern is horizontal, covering the platysmal bands and central neck
• Slightly increased risk of visibility or small lumps, which typically resolve in 24–48 hours

Treatment Protocol & Expected Results

Profhilo is typically administered through a structured two-session protocol, with each session spaced approximately four weeks apart. This timing is essential to allow the first treatment to initiate cellular regeneration and hydration while the second reinforces collagen and elastin synthesis. In most cases, this dual approach offers optimal bioremodeling outcomes, particularly in areas prone to skin laxity and dehydration, such as the face and neck.

What to Expect After Each Session

Patients generally experience an initial boost in skin hydration within the first few days post-treatment. This is followed by visible improvements in skin tone, elasticity, and firmness between weeks three and six, as neocollagenesis and elastin remodeling occur. The full effect tends to peak around week six, showcasing natural radiance and smoother skin texture.

Some patients may notice minor swelling or small lumps at the injection sites, especially in the neck area. These are common and usually resolve within 24 to 48 hours without intervention.

Maintenance Recommendations

To maintain the results, a single follow-up session is advised every 6 to 9 months. Patients with more advanced skin aging or increased environmental stressors (e.g., smoking, sun exposure) may benefit from more frequent maintenance treatments, tailored by the clinician.

Combining with Other Aesthetic Procedures

Profhilo works exceptionally well in synergy with other modalities, but timing is crucial. Energy-based devices such as radiofrequency or ultrasound treatments should be administered either 2 weeks before or after Profhilo. Microneedling, mesotherapy, and neuromodulators can be strategically spaced out based on the individual treatment plan. Dermal fillers should not be used in the same anatomical area or session, to avoid disrupting the even diffusion of Profhilo and to minimize adverse reactions.

Profhilo Results: A Summary

• Deep tissue hydration without altering facial volume
• Enhanced elasticity and firmness across treated areas
• Refined skin texture and luminous glow
• Reduction in superficial wrinkles and fine lines
• No downtime aside from minor, temporary injection site effects

By following this protocol, both clinicians and patients can expect consistent, safe, and visibly rejuvenating results from this next-generation skin bioremodeling treatment. Want to know how long does Profhilo last? Read more on the topic on our blog.

Ideal Candidates

Profhilo treatment is best for:

• Adults aged 30–60 experiencing early signs of aging
• Patients with dehydrated, crepey, or sagging skin
• Those who want subtle, non-volumizing rejuvenation

Profhilo Injection Points Aftercare and Safety Considerations

To ensure optimal outcomes and reduce side effects such as Profhilo lumps:

Aftercare Tips:

• Avoid makeup for 12 hours
• No strenuous activity or alcohol for 24 hours
• Skip facials or massages for 1 week

Injection Depth:

• Face: deep dermis/just above SMAS
• Neck: superficial subcutaneous

Incorrect depth can cause visible lumps or reduced effectiveness. Curious about what happens if Profhilo is injected too deep? The product may fail to diffuse properly, or worse, cause tissue irregularity.

FAQs

How long does Profhilo last?

About 6 months, with maintenance recommended every 6–9 months.

How long does Profhilo take to work?

Initial glow within a few days, full results in 3–6 weeks.

How deep to inject Profhilo?

Face: deep dermis, Neck: superficial subcutis.

What happens if Profhilo is injected too deep?

Risk of poor diffusion and visible irregularities.

Does Profhilo leave lumps?

Sometimes small lumps appear at injection sites but usually resolve within 24–48 hours.

Sources

1. Stellavato A, Corsuto L, D’Agostino A, et al. Hyaluronan Hybrid Cooperative Complexes as a Novel Frontier for Cellular Bioprocesses Re-Activation. PLoS One. 2016;11(10):e0163510. Published 2016 Oct 10. doi:10.1371/journal.pone.0163510 https://pubmed.ncbi.nlm.nih.gov/27723763/
2. Cassuto D, Cigni C, Bellia G, Schiraldi C. Restoring adipose tissue homeostasis in response to aging: initial clinical experience with Profhilo Structura®. Gels. 2023;9(8):614. doi:10.3390/gels9080614 https://shorturl.at/fD31k 

Andre P. Hyaluronic acid and its use as a “rejuvenation” agent in cosmetic dermatology. Semin Cutan Med Surg. 2004;23(4):218-222. doi:10.1016/j.sder.2004.09.002 https://pubmed.ncbi.nlm.nih.gov/15745228/