Profhilo Aftercare: Steps and Routines for Getting the Best Results

Key Takeaways

• Profhilo is a unique injectable that hydrates and remodels skin, but proper aftercare is key to optimal results.
• Profhilo aftercare includes avoiding strenuous activity, alcohol, sun exposure, and makeup for at least 24 to 48 hours post-treatment.
• Mild swelling, redness, or small lumps are common and typically resolve within a few days.
• Long-term results are enhanced by good skincare, hydration, and avoiding UV exposure.
• Know when side effects are normal—and when they may signal a problem.

What Is Profhilo and How Does It Work?

Before diving into Profhilo aftercare, it’s important to briefly understand what Profhilo is and how it differs from other injectables.

Profhilo is a skin booster, not a traditional filler. It contains one of the highest concentrations of pure hyaluronic acid (HA) available, but instead of adding volume or contouring features, it works by deeply hydrating the skin and stimulating the natural production of collagen and elastin. This dual action helps to firm, smooth, and rejuvenate skin from within.

Unlike traditional fillers, Profhilo is injected using the Bio Aesthetic Points (BAP) technique across five specific areas on each side of the face. These injections form small deposits under the skin that gradually diffuse, triggering tissue remodeling over several weeks.

For more on injection technique, see our post on the 5 Profhilo injection points.

Immediate Profhilo Aftercare: The First 24–48 Hours

After a Profhilo injection, the first two days are crucial. This is when the body begins integrating the hyaluronic acid, and the skin is most vulnerable to irritation, inflammation, and infection.

Post-treatment guidelines include:

• Avoid touching or rubbing the treated areas. This helps reduce the risk of infection or unintentional displacement of the product.
• No makeup for 24 hours. Makeup can introduce bacteria and clog pores, increasing the risk of irritation or breakouts.
• Avoid alcohol, spicy foods, and hot drinks. These can exacerbate redness or swelling.
• No intense exercise. Increased blood flow and sweating may worsen bruising or disrupt early product diffusion.
• Stay cool. Saunas, steam rooms, and hot showers should be avoided as heat can cause inflammation or prolong swelling.

For a more detailed breakdown of early side effects like small bumps or swelling, read our guide on Profhilo lumps.

What to Avoid After Profhilo Treatment

Certain activities and habits can interfere with Profhilo results, especially in the first few days after your session. Medical professionals should always communicate these do’s and don’ts clearly to patients to ensure both safety and satisfaction.

Avoid the following post-Profhilo:

• Excessive facial movement (e.g., massages, facials, dental appointments) for at least 48 hours
• Sleeping on your side or face down for at least one night to prevent pressure on injection sites
• Direct sun exposure or tanning beds for at least a week
• Smoking, as it compromises skin oxygenation and collagen production
• Over-the-counter anti-inflammatory medications like ibuprofen, unless recommended by your provider

What’s Normal After Profhilo (And What’s Not)

It’s perfectly normal to experience some mild reactions after Profhilo injections. These typically resolve quickly and are a natural part of the treatment process.

Normal side effects include:

• Mild redness or swelling at injection sites
• Small, mosquito-bite-sized bumps (these usually flatten within 24–72 hours)
• Bruising in some patients, particularly those prone to it

What’s not normal:

• Severe pain or swelling that worsens after 48 hours
• Hard, persistent nodules that don’t soften within 7–10 days
• Signs of infection, such as heat, pus, or significant tenderness
• Allergic reactions, although extremely rare due to the purity of Profhilo’s non-animal-derived HA

If any unusual or prolonged symptoms occur, patients should contact their aesthetic practitioner immediately. For more insight into complications and patient safety, read our article on Profhilo gone wrong.

How Long Do Side Effects Last?

Most patients recover quickly from Profhilo injections. Here’s a general timeline:

• Redness or swelling: Usually subsides within a few hours
• Lumps or bumps: Typically disappear in 1–3 days
• Bruising: May last up to a week, depending on the individual

This fast recovery makes Profhilo a convenient “lunchtime treatment” with minimal downtime.

Long-Term Profhilo Aftercare and Maintenance Tips

After the initial post-treatment phase, long-term skincare and healthy lifestyle habits can greatly enhance the outcome of a Profhilo skin booster treatment.

Tips to maintain results:

• Hydrate regularly. HA attracts water, and staying hydrated boosts the treatment’s effects.
• Use broad-spectrum SPF daily. UV exposure degrades collagen and hyaluronic acid.
• Incorporate antioxidant-rich skincare, like Vitamin C serums, to support skin health.
• Consider complementary treatments, such as light chemical peels or microneedling, if appropriate.
• Schedule maintenance sessions every 6–9 months to preserve results.

When showing patients Profhilo before and after photos, be sure to explain that results are subtle but significant, focused on skin quality, not facial volume.

Frequently Asked Questions (FAQ)

When can I wash my face after Profhilo?

You can gently wash your face about 6–8 hours after your Profhilo treatment, ideally using a mild, fragrance-free cleanser. However, it’s best to wait until the next morning to avoid disrupting the injection sites. Avoid exfoliants, scrubbing, or hot water for at least 48 hours. Keeping the area clean but undisturbed supports optimal healing and minimizes the risk of irritation or infection.

How long does it take to recover from Profhilo?

Most patients experience only minor swelling, redness, or small bumps, which typically subside within 24 to 72 hours. Bruising may last up to a week for some individuals. Full recovery, in terms of visible side effects, is usually complete within 3–5 days. The collagen and elastin-boosting effects of Profhilo continue developing over 4–6 weeks, especially after the second treatment.

How long after Profhilo can I sleep on my side?

It’s recommended to sleep on your back for the first 1–2 nights after your Profhilo injection. Sleeping on your side too soon can put pressure on the injection sites, potentially affecting product diffusion and increasing the risk of uneven results or mild swelling. After 48 hours, side-sleeping is generally safe unless your provider advises otherwise.

Where are the 5 injection points for Profhilo?

The Bio Aesthetic Points (BAP) technique used for Profhilo involves five strategic injection sites on each side of the face:

1. Zygomatic Protrusion (cheekbone area)
2. Nasal base (next to the nostrils)
3. Chin
4. Mandibular angle (jawline)
5. Tragus area (in front of the ear)

What are the rules for Profhilo aftercare?

Aftercare rules are crucial for safe healing and achieving the best results. These include:

• No touching or massaging the treated areas for at least 24 hours
• Avoid makeup, alcohol, exercise, and sun exposure for 48 hours
• Sleep on your back, not your side, the first night or two
• Skip facials, dental visits, or other facial treatments for 7–10 days
• Stay hydrated and follow your practitioner’s advice closely

Final Thoughts

Profhilo is a powerful skin rejuvenation treatment when performed correctly and followed with proper aftercare. For both injectors and patients, understanding the recovery process and supporting the body’s healing timeline is the key to success.

Medical professionals should always emphasize realistic outcomes, explain the difference between normal healing responses and potential complications, and encourage regular follow-up visits. With the right support and attention, Profhilo’s collagen-stimulating effects can lead to beautiful, glowing skin, without downtime or drama.

Looking to stock up for your clinic? Here’s where to buy Profhilo at wholesale pricing.

Sources

1. Carruthers JDA, Glogau RG, Blitzer A; Facial Aesthetics Consensus Group Faculty. Advances in facial rejuvenation: botulinum toxin type a, hyaluronic acid dermal fillers, and combination therapies–consensus recommendations. Plast Reconstr Surg. 2008;121(5 Suppl):5S-30S. doi:10.1097/PRS.0b013e31816de8d0 https://pubmed.ncbi.nlm.nih.gov/18449026/ 
2. Bravo B, Correia P, Gonçalves Junior JE, Sant’Anna B, Kerob D. Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence. Dermatol Ther. 2022;35(12):e15903. doi:10.1111/dth.15903 https://pubmed.ncbi.nlm.nih.gov/36200921/ 
3. Walker K, Basehore BM, Goyal A, et al. Hyaluronic Acid. [Updated 2023 Jul 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482440/