Polynucleotide Treatment Explained: Why Polynucleotides Are the Next Big Thing in Regenerative Aesthetics

Understanding Polynucleotide Treatment in Aesthetic Medicine

Polynucleotide treatment is rapidly gaining traction in the world of regenerative aesthetics as an innovative solution for skin and hair rejuvenation. But what exactly is polynucleotide treatment, and why is it considered a game-changer in aesthetic medicine?

Polynucleotides are natural DNA fragments that work at a cellular level to promote tissue repair, hydration, and collagen stimulation. Unlike traditional fillers, which primarily add volume, polynucleotide injections enhance skin quality by improving its structure, elasticity, and regenerative capacity. This makes them ideal for addressing concerns such as fine lines, wrinkles, skin laxity, and even hair thinning.

In this article, we will explore the science behind polynucleotide treatment, its benefits, applications, and how it compares to other aesthetic treatments like PRP (platelet-rich plasma) and HA (hyaluronic acid) fillers.

What Are Polynucleotides and How Do They Work?

Polynucleotides (PN) are biocompatible molecules derived from purified salmon or trout DNA. These fragments are processed to ensure they are safe for human use and free from immunogenic properties.

Mechanism of Action

• Fibroblast Stimulation – Polynucleotides activate fibroblast cells, which are essential for collagen and elastin production, leading to firmer, healthier skin.
• Deep Hydration – They attract and retain moisture within the skin, enhancing hydration and reducing signs of dryness and dullness.
• Anti-Inflammatory Properties – Polynucleotides reduce oxidative stress and inflammation, making them suitable for sensitive skin types and those prone to redness or irritation.

Tissue Regeneration – By accelerating cellular turnover and repair, polynucleotide injections help to heal damaged skin, improve scars, and promote overall rejuvenation.

Key Benefits of Polynucleotide Treatment

Unlike traditional aesthetic procedures that primarily focus on volume restoration or surface-level hydration, polynucleotides work at a deeper level, actively repairing and regenerating skin tissues for long-term improvements. Their ability to stimulate cellular repair, enhance hydration, and promote collagen production makes them a standout option in regenerative aesthetics.

1. Enhanced Skin Regeneration and Tissue Repair

Polynucleotides work by activating fibroblasts, the key cells responsible for collagen and elastin production. This cellular activation leads to progressive improvements in skin texture, firmness, and resilience over time. Additionally, polynucleotides play a crucial role in tissue repair, making them highly effective for treating post-acne scars, sun damage, and even stretch marks.

2. Deep Hydration and Elasticity Boost

Polynucleotide-based therapy improves hydration at a structural level, reinforcing the skin’s ability to hold moisture on its own. In addition to hydration, polynucleotides improve skin elasticity by enhancing collagen and elastin synthesis. By strengthening the skin’s natural support system, polynucleotides help maintain a lifted and youthful appearance, reducing the early signs of aging.

3. Safe, Natural, and Biocompatible for All Skin Types

Polynucleotide treatments stand out due to their high biocompatibility, making them a safe and effective option for a broad range of skin types. Due to their anti-inflammatory and antioxidant properties, polynucleotides help calm redness and irritation, making them ideal for post-procedure recovery or skin that is prone to environmental stressors.

4. Powerful Anti-Aging Effects and Wrinkle Reduction

Polynucleotides offer a subtle and natural transformation, gradually improving the quality and thickness of the skin. This makes them an excellent option for patients looking to reduce fine lines and wrinkles without the risk of an overfilled or artificial appearance, especially at the under-eye region, neck and décolletage area, and the hands. This gradual yet transformative approach ensures that the skin appears naturally refreshed, rather than drastically altered.

5. Effective for Hair Restoration and Scalp Health

These treatments are not limited to skin rejuvenation — they also play a critical role in hair restoration. Polynucleotide injections work by stimulating follicular stem cells, improving blood circulation, and enhancing scalp hydration, which are all essential for stronger, healthier hair growth.

Polynucleotide Treatment Applications

1. Facial Rejuvenation

The treatments improve skin texture, hydration, and elasticity, making them ideal for patients looking for long-term anti-aging solutions.

2. Under-Eye Rejuvenation

Injection of polynucleotides under eyes effectively treats dark circles, fine lines, and crepey under-eye skin, providing a refreshed and natural appearance.

They accelerate wound healing and reduce the appearance of acne scars, surgical scars, and stretch marks by enhancing skin regeneration.

4. Hair Restoration

By improving blood circulation and stimulating hair follicles, polynucleotide treatments support hair growth and scalp health.

Polynucleotides vs Other Aesthetic Treatments

Treatment	Primary Function	Longevity of Results	Best For
Polynucleotides	Stimulates collagen, repairs tissue, hydrates skin	6-12 months	Skin regeneration, hydration, fine lines
Hyaluronic Acid Fillers	Adds volume, fills wrinkles	6-24 months	Facial volume restoration, deep wrinkles
PRP (Platelet-Rich Plasma)	Uses growth factors to rejuvenate skin	6-12 months	Skin texture improvement, hair restoration
Skin Boosters	Hydration and mild collagen stimulation	3-9 months	Hydration, fine-line reduction

Leading Polynucleotide Brands

For medical practitioners who are looking to obtain polynucleotide treatments for their practice, the following brands offer high-quality solutions:

• Nucleofill – A well-known polynucleotide skin booster that enhances hydration and collagen production. Their Nucleofill Medium Plus and Nucleofill Strong are particularly sought-after.
• PhilArt – Another line of effective polynucleotide treatments that target skin laxity and fine lines: Croma PhilArt and Croma PhilArt Next are very popular.

FAQs About Polynucleotide Treatment

How Long Does the Polynucleotide Treatment Last?

The effects of polynucleotide treatment typically last between 6 to 12 months, depending on factors such as skin type, lifestyle, and maintenance treatments. Most patients require an initial series of 3–4 treatments spaced 2–4 weeks apart, followed by maintenance sessions every 6–12 months to sustain results.

Is Polynucleotide Better Than Botox?

While Botox works by temporarily relaxing muscles to reduce wrinkles, polynucleotides focus on skin quality, hydration, and collagen stimulation. Polynucleotides regenerate the skin at a cellular level, improving hydration, elasticity, and overall skin quality. Many patients opt for both treatments in combination for comprehensive anti-aging results.

How Much Does Polynucleotide Treatment Cost?

The cost of polynucleotide treatment varies based on the clinic, location, and number of sessions required. In the UK, prices generally range between £250 and £600 per session, with a full treatment course (3–4 sessions) costing between £750 and £2,000. More advanced treatments, such as under-eye polynucleotide therapy or scalp rejuvenation, may fall at the higher end of the pricing spectrum.

How Painful Is Polynucleotide Treatment?

While polynucleotide injections are minimally painful, patients may experience mild discomfort, redness, or swelling at the injection sites. Compared to more invasive aesthetic procedures, polynucleotide treatments have a low pain profile and minimal downtime, making them an attractive option for skin and hair rejuvenation.

Final Thoughts

Polynucleotide treatment is redefining regenerative aesthetics by offering a natural and effective solution for skin and hair rejuvenation. Unlike traditional fillers that provide immediate volume, polynucleotides work progressively to enhance collagen production, hydration, and tissue repair.

For medical aestheticians looking to buy polynucleotides and stay ahead in the field of aesthetic medicine, incorporating polynucleotide treatments into their practice is a forward-thinking investment. Explore our range of polynucleotide products to start offering this cutting-edge treatment today.