Polynucleotide Injections: Brands, Benefits, Procedure, and Results

Understanding Polynucleotide Injections

Polynucleotide injections are an advanced regenerative aesthetic treatment designed to revitalize the skin by deeply hydrating tissues, stimulating collagen production, and accelerating cellular repair. Unlike traditional dermal fillers that focus on volume enhancement, polynucleotides work at a biological level, repairing damaged skin, improving elasticity, and restoring a youthful glow over time. These treatments are increasingly popular among aestheticians due to their long-term benefits, minimal downtime, and ability to deliver natural-looking results. Medical professionals looking to buy polynucleotide injections can do so through Best Buy Fillers shop.

How Do Polynucleotide Injections Work?

Polynucleotides are purified DNA fragments derived from natural sources, often salmon or trout. These DNA molecules are highly biocompatible and serve as powerful bio-stimulators within the skin. Once injected, polynucleotides trigger multiple regenerative processes, including:

• Collagen and Elastin Stimulation: Polynucleotides activate fibroblast cells, leading to the production of essential structural proteins that improve skin firmness and elasticity.
• Intense Hydration: They have hydrophilic properties, meaning they attract and retain moisture in the skin, improving hydration levels and smoothing fine lines.
• Cellular Regeneration: By promoting tissue repair, polynucleotides help reduce signs of aging, acne scarring, and skin laxity.
• Anti-Inflammatory Action: They reduce oxidative stress and inflammation, making them an ideal choice for sensitive or rosacea-prone skin.
• Improved Microcirculation: Polynucleotides boost blood flow to treated areas, enhancing oxygen and nutrient delivery for a healthier, more radiant complexion.

Leading Polynucleotide Injection Brands

There are several high-quality polynucleotide brands on the market, each offering unique formulations tailored to different skin concerns. Among the most trusted and effective brands available from Best Buy Fillers are:

Nucleofill

Nucleofill is a leading polynucleotide-based biostimulator designed to enhance skin quality and promote tissue regeneration. It’s used to:

• Reduce under-eye hollows and fine lines with Nucleofill Soft Plus
• Rejuvenate facial and neck skin with Nucleofill Strong  
• Enhance skin hydration and elasticity with Nucleofill Medium
• Support post-procedure recovery

Nucleofill’s unique formulation ensures gradual yet long-lasting improvement, making it a staple in aesthetic clinics.

PhilArt

PhilArt is another cutting-edge polynucleotide injectable known for its regenerative properties. It is especially effective for:

• Smoothing wrinkles and fine lines, especially Croma PhilArt NEXT
• Enhancing overall skin texture and tone with Croma PhilArt
• Stimulating fibroblast activity for collagen production
• Providing deep hydration to dry, tired skin

Both Nucleofill and PhilArt are sought-after options for practitioners looking to order polynucleotides and aiming to offer natural yet noticeable rejuvenation treatments.

Benefits of Polynucleotide Injection

Polynucleotide injections offer a range of benefits, making them a sought-after treatment for both aesthetic and therapeutic applications. These advantages stem from their ability to stimulate cellular regeneration, improve hydration, and enhance skin quality at a deeper level. Below are some of the most notable benefits:

1. Enhanced Skin Hydration and Elasticity

Polynucleotides work by attracting water molecules and improving skin moisture retention. This results in a plumper, more hydrated complexion, reducing the appearance of fine lines and wrinkles. Unlike conventional dermal fillers, which add volume, polynucleotides enhance the skin’s ability to retain moisture naturally.

2. Stimulation of Collagen and Elastin Production

One of the standout benefits of polynucleotide injections is their ability to trigger fibroblast activity, leading to increased collagen and elastin production. This makes them an excellent option for individuals seeking long-term skin improvement, as collagen synthesis continues for weeks after treatment, leading to firmer, more youthful skin.

3. Tissue Regeneration and Wound Healing

Polynucleotides are derived from DNA fragments that have regenerative properties, helping repair damaged skin and accelerate wound healing. This makes them particularly beneficial for patients with acne scars, surgical scars, or post-inflammatory hyperpigmentation.

4. Anti-Inflammatory and Antioxidant Properties

Due to their natural anti-inflammatory effects, polynucleotide injections can help calm redness, irritation, and inflammation. They are suitable for individuals with sensitive skin, rosacea, or other inflammatory skin conditions, making them a gentler alternative to more aggressive treatments.

5. Safe for Delicate Areas

Unlike certain fillers that can lead to complications in delicate areas like under the eyes, polynucleotide injections offer a safer, more natural-looking solution. They improve skin texture and thickness under the eyes, reducing dark circles and hollowing without the risk of excessive swelling or puffiness.

6. Suitable for Various Skin Types and Ages

Polynucleotide treatments cater to a wide range of patients, from younger individuals looking for preventive care to older patients seeking to restore lost elasticity and hydration. They can be used on the face, neck, décolletage, and even hands to rejuvenate aging skin.

The Polynucleotide Injection Procedure

The treatment process is simple and well-tolerated, following these key steps:

• Consultation: A medical aesthetician evaluates the patient’s skin concerns and recommends an appropriate treatment plan.
• Preparation: The treatment area is thoroughly cleansed, and a numbing cream may be applied to minimize discomfort.
• Injection Process: Polynucleotides are injected using a fine needle or cannula, strategically placed to maximize their regenerative effects.
• Post-Treatment Care: Patients are advised to avoid intense exercise, direct sun exposure, and active skincare ingredients (such as retinol) for 48 hours to ensure optimal healing.

Polynucleotide Injection Before and After: What to Expect

The effects of polynucleotide injections develop gradually, as the treatment stimulates the body’s natural regeneration processes. Understanding the before and after expectations can help both patients and medical professionals optimize results.

Before the Treatment

Patients should undergo a thorough consultation where their medical history, skin concerns, and treatment goals are assessed. Aesthetic practitioners should provide clear expectations, emphasizing that polynucleotides do not provide instant volume like traditional fillers but rather work overtime to improve skin quality.

To minimize risks, patients should:

• Avoid blood-thinning medications like aspirin or ibuprofen for at least 48 hours before treatment.
• Refrain from alcohol consumption, as it can increase the likelihood of bruising.
• Stay hydrated and maintain a good skincare routine leading up to the appointment.

Immediately After the Procedure

Following injection, mild redness, swelling, and tenderness at the treatment site are common. These effects usually resolve within a few days. Patients may also notice a slight “lifting” effect due to initial fluid retention, which subsides as the polynucleotides integrate into the skin.

Long-Term Results

Unlike HA fillers, which provide immediate volume enhancement, polynucleotide injections work over several weeks to stimulate collagen production and improve skin texture. Patients typically observe noticeable improvements in:

• Skin elasticity and firmness – Fine lines and wrinkles appear softer, and overall skin quality is enhanced.
• Hydration levels – The skin retains moisture better, resulting in a more radiant complexion.
• Reduction of under-eye hollowing and dark circles – Polynucleotides strengthen the delicate under-eye skin, making it appear less tired and saggy.

For optimal results, a series of treatments (typically 2-3 sessions spaced 2-4 weeks apart) is recommended. Results can last between 6-12 months, depending on individual skin conditions and lifestyle factors.

Side Effects of Polynucleotide Injection

Polynucleotide injection side effects are generally mild, however, some patients may experience:

• Mild swelling, redness, or tenderness at the injection site
• Temporary bruising or sensitivity
• Rare cases of itchiness or minor discomfort

These effects typically resolve within a few days. Practitioners should ensure proper injection techniques to minimize risks and enhance patient comfort.

Comparing Polynucleotide Injection to Other Aesthetic Treatments

Polynucleotides vs. Hyaluronic Acid Fillers

Feature	Polynucleotide Injections	Hyaluronic Acid Fillers
Purpose	Skin hydration, rejuvenation, and repair	Instant volume and wrinkle reduction
Mechanism	Stimulates collagen and elastin production	Adds temporary volume
Longevity	Long-term improvements with ongoing benefits	6–12 months before re-treatment
Best For	Fine lines, skin texture, elasticity	Facial contouring, deep wrinkles

Polynucleotides vs. PRP (Platelet-Rich Plasma) Therapy

Feature	Polynucleotide Injections	PRP Therapy
Source	DNA-based regenerative biostimulation	Uses the patient’s own blood components
Sessions Needed	2–3 sessions for optimal results	Requires frequent maintenance
Hydration Benefits	Provides deep, lasting hydration	Limited hydration effect

Where to Buy Polynucleotide Injection

Medical professionals interested in incorporating polynucleotide treatments into their practice can purchase high-quality products like Nucleofill and PhilArt from:

• Buy Nucleofill products
• Buy PhilArt products

These trusted brands offer clinically tested formulations for superior patient results.

Conclusion

Polynucleotide injections are revolutionizing aesthetic medicine by offering a natural and scientifically backed solution for skin rejuvenation. Their ability to stimulate collagen, enhance hydration, and improve overall skin quality makes them an essential treatment for medical aestheticians. Whether targeting under-eye hollows, fine lines, or overall skin aging, polynucleotides provide a long-term, regenerative approach to beauty and skin health.