How Long Does Profhilo Take to Work? A Week-by-Week Timeline

Key Takeaways

• Profhilo provides immediate hydration but visible firming and skin quality improvements develop over several weeks.
• How long does Profhilo take to work? Most patients begin seeing smoother texture and glow by week 2.
• Peak results, including increased elasticity and firmness, occur around weeks 6 to 8.
• Two sessions, spaced 4 weeks apart, are required for full bioremodeling effects.
• Aftercare and healthy habits significantly impact the outcome and longevity of results.

What Is Profhilo and How It Works Over Time

Profhilo is a unique injectable skin bioremodeling treatment that contains high concentrations of stabilized hyaluronic acid (HA). So, how long does Profhilo take to work? Unlike traditional dermal fillers, which volumize specific areas, Profhilo spreads evenly beneath the skin over time to deliver two main actions:

• Immediate hydration: The high molecular weight HA attracts and retains water, boosting skin moisture within days.
• Gradual biostimulation: Over the next few weeks, Profhilo stimulates the production of collagen and elastin, improving firmness, elasticity, and overall skin quality.

It’s important to communicate that Profhilo does not provide instant volumizing effects. Instead, results emerge gradually, making it ideal for patients who want subtle, natural rejuvenation without looking “done.” We wrote about ideal Profhilo injection points on our blog for anyone looking for more in-depth knowledge on the topic.

Week-by-Week Breakdown After First Session

Week 1: Hydration Boost and Initial Response

Immediately following the first Profhilo session, most patients report mild swelling or tenderness at injection points, which resolves within 24–48 hours. During this time, the skin begins to absorb the HA and retain moisture.

• Skin may appear slightly plumper and more hydrated
• Any visible bumps or lumps subside quickly
• A subtle, dewy glow might be noticeable by the end of the week

Week 2: Smoother Texture Begins

By the second week, the initial hydration effect becomes more evident. Many patients begin to notice:

• Smoother skin texture
• A more refreshed appearance
• Early signs of firmness in treated areas

Although these changes are mild, they mark the beginning of the biostimulation process.

Week 3–4: Radiance and Elasticity Improve

• The production of new collagen and elastin starts to pick up around this period. Patients may observe:
• Enhanced skin tone and elasticity
• Brighter complexion
• A firmer, lifted feel without added volume

This is often when practitioners and patients alike start seeing more noticeable transformations.

Week 4–6: Second Session Administered

Profhilo is designed to be administered in two sessions spaced approximately four weeks apart. The second session reinforces the skin’s regenerative response.

After this session:

• Results compound, building on the first injection’s effect
• The skin continues to remodel itself from within

Post-Second Session Progression

Week 6–8: Peak Results

Around weeks 6 to 8, patients typically experience the full benefits of Profhilo. This is when:

• Collagen and elastin production peaks
• Skin appears visibly firmer, smoother, and more radiant
• Fine lines and crepiness are reduced, especially in delicate areas like the neck or under the eyes

These effects are subtle yet powerful, delivering a natural, rejuvenated appearance without exaggerated volume.

Week 8+: Ongoing Improvements

Some patients report continued skin improvements even into the third month, particularly in tone and hydration.

Read more about it in our article: How Long Does Profhilo Last?

When to Expect Results to Plateau

Profhilo results typically plateau between 8 to 12 weeks after the second treatment. Patients can expect benefits to last up to 6 months, depending on individual factors such as skin condition, age, and lifestyle.

Maintenance Expectations

• Most professionals recommend repeat treatments every 6 months to maintain optimal results.
• For aging or sun-damaged skin, three sessions may be ideal during the first year.

Medical professionals looking for quality products can order Profhilo online from trusted distributors such as Best Buy Fillers.

How to Support the Process

Post-Treatment Aftercare

Proper aftercare enhances results and minimizes side effects:

• Avoid touching or massaging the treated areas for 24 hours
• Refrain from heavy exercise, saunas, or alcohol for 48 hours
• Skip makeup for the first 12 hours

Lifestyle and Skincare Tips

Supporting the skin during Profhilo treatment helps extend its effects:

• Use gentle, hydrating skincare products with hyaluronic acid or ceramides
• Apply broad-spectrum SPF daily to prevent breakdown of new collagen
• Maintain a nutritious diet rich in antioxidants
• Avoid smoking and excessive sun exposure, which accelerate skin aging

FAQs

How quickly do you see results from Profhilo?

Initial hydration and glow can appear within a few days to a week, but firmness and collagen improvement peak around 6–8 weeks.

Is one session of Profhilo enough?

No. Two sessions spaced one month apart are required for full results. In some cases, a third session may be recommended.

Where does Profhilo work best?

Profhilo is most commonly used on the face and neck, but it also works well for the hands, arms, and décolletage.

What is the best age for Profhilo?

It is suitable for patients aged 30 and above showing early signs of skin laxity, dryness, or dullness.

What to avoid after Profhilo?

Avoid alcohol, makeup, heat exposure, and intense exercise for 24–48 hours post-treatment.

Conclusion: Setting the Right Expectations

Profhilo is not a quick fix, but its gradual transformation delivers truly natural-looking skin rejuvenation. Understanding how long Profhilo takes to work, and when to expect changes, helps aestheticians guide their patients with transparency and confidence.

By emphasizing a realistic timeline, along with strategic aftercare and maintenance, practitioners can help patients achieve radiant, healthier-looking skin without over-promising or under-delivering.

Sources

1. Stellavato A, Corsuto L, D’Agostino A, et al. Hyaluronan Hybrid Cooperative Complexes as a Novel Frontier for Cellular Bioprocesses Re-Activation. PLoS One. 2016;11(10):e0163510. Published 2016 Oct 10. doi:10.1371/journal.pone.0163510 https://pubmed.ncbi.nlm.nih.gov/27723763/ 
2. Cassuto D, Cigni C, Bellia G, Schiraldi C. Restoring adipose tissue homeostasis in response to aging: initial clinical experience with Profhilo Structura®. Gels. 2023;9(8):614. doi:10.3390/gels9080614 https://shorturl.at/fD31k  
3. Sundaram H, Liew S, Signorini M, et al. Global Aesthetics Consensus: Hyaluronic Acid Fillers and Botulinum Toxin Type A-Recommendations for Combined Treatment and Optimizing Outcomes in Diverse Patient Populations. Plast Reconstr Surg. 2016;137(5):1410-1423. doi:10.1097/PRS.0000000000002119 https://pubmed.ncbi.nlm.nih.gov/27119917/