Collagen Biostimulators Before and After: How They Transform Skin Over Time

Biostimulators are experiencing a growing popularity among medical professionals, thanks to their ability to improve skin quality and promote renewal by activating the skin’s natural processes such as collagen production. If you are an medical aesthetician looking to buy biostimulators and offer their benefits to your clients, this article will help you understand the before and after results of this powerful treatment.

How Collagen Biostimulators Work

Biostimulators are innovative injectables used to stimulate the body’s natural production of collagen. By doing so, they improve skin elasticity, texture and firmness. However, they offer gradual enhancements by boosting the skin’s natural rejuvenation process, unlike traditional fillers where the progress is noticeable instantly. Biostimulators are beneficial for different facial areas such as the jawline, cheeks, and nasolabial folds. 

What Types of Biostimulators Are There?

There are two main types of biostimulators: the ones based on hyaluronic acid and non-HA-based. Of course, each category has its own perks. For instance, hyaluronic acid biostimulators offer better skin hydration with certain aspects of collagen stimulations. On the other hand, non-HA-based treatments bring better collagen stimulation with minor to modest changes in volume. They do not hydrate the skin like the injectables based on hyaluronic acid do. Therefore, patients in their 40s would reap the highest benefits by combining both HA and non-HA-based injectables in their aesthetic treatment regimen. 

When Can Patients See the Results?

Patients with dehydrated skin can notice the first changes within one to two weeks as the treatment works intensely to rehydrate the dermis. However, skin tightening and firming may take up to 6 months since new collagen needs time to regenerate. 

How Many Treatments Are Needed?

As with all other aesthetic injectables, the number of treatments varies depending on the patient’s current skin condition, as well as the exact product used. With biostimulator injections, patients usually need 2 to 4 treatments, depending on their level of collagen loss, as well as dermal hydration. 

As for age groups, this is what it usually looks like: 

• 30s to mid 40s: 2 sessions
• 40s to mid 50s: 3 sessions
• 50s to 60s and older: 3-4 sessions

When Should Patients Start Using Biostimulators?

The ideal age to start using biostimulator injectables is in the early stages of collagen loss, and that would be in the early 30s. Collagen depletion begins sometime in the early 20s, and it occurs at 1-1.5% per year. Therefore, the earlier a patient starts using the treatment, the fewer sessions they will need in the future. 

Visual Improvements in Common Treatment Areas

Biostimulators are most commonly used to correct imperfections in the facial, neck, and body areas, so let’s take a look at some of the real results of this powerful treatment:

Face

The majority of clients are interested in the benefits of biostimulators in the facial area, so we covered the most common categories with before and after images that can show you visible results:

• Cheeks – The treatment can restore lost volume and contour. 

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• Jawline – Visibly define and lift sagging skin.

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• Nasolabial Folds: The treatment is used to smooth deep wrinkles and folds.

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• Under-Eye Area: Improved texture and reductions in hollowness.

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Neck and Décolletage

Collagen biostimulators can help the patients tighten and firm the gentle skin of the neck and chest, reducing visible signs of ageing and the unwanted crepey texture. 

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Body

When it comes to the body, biostimulators are mostly used to improve skin laxity and texture in areas such as the abdomen, arms, and thighs. 

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The Benefits of Biostimulators Over Traditional Fillers

More and more medical professionals choose biostimulators over traditional fillers, and here are the reasons why:

Natural-Looking Results

The concept of “natural beauty” is now more dominant than exaggerated cosmetic enhancements. Today’s clients prefer aesthetic treatments that can restore their youthful appearance in a subtle way, without making the changes too obvious. So when choosing between skin booster vs biostimulator injectables, medical professionals frequently suggest the latter. Since these treatments work gradually to stimulate collagen, their results appear more organic, blending perfectly with the current skin texture. 

Addressing Facial Volume Loss

The loss of facial volume is one of the most common signs of ageing. This is an issue that traditional fillers can correct only temporarily and without addressing the root cause which is a decrease in collagen. Biostimulator injections, on the other hand, stand as an innovative solution that targets collagen depletion. They help the skin restore the lost volume and smooth out the existing wrinkles while also showing a more revitalised appearance. 

Improved Skin Structure

When the skin ages, it loses volume, but it also suffers from a decline in structural integrity. This is where the ability of biostimulators to strengthen the skin from within is crucial. The treatment restores skin structure and makes it firmer and more resilient by boosting the levels of collagen. Traditional fillers do not offer such advantages since they mainly target surface-level concerns. 

Lasting Effects

One of the most appealing benefits of collagen biostimulators is certainly the longevity of the results. Unlike traditional dermal fillers that may need retouching every six to twelve months, the effects of these advanced fillers can last up to two years. As such, biostimulators present a cost-effective solution, and also a pretty convenient option for patients who do not enjoy frequent visits to the clinic.

Customisable Treatments

The gradual nature of biostimulator injections also allows for a more customised treatment plan. Since the results develop over time, aestheticians can adjust the number of sessions and even change the injection sites to help the patients achieve the desired look. 

Conclusion

Collagen biostimulators gradually improve skin texture, firmness and volume by boosting the skin’s natural production of collagen. As a medical professional, you must be considering the use of these innovative injectables in your practice, so seeing the before and after images that showcase actual results must have helped you understand the power of collagen biostimulators.

References: 

Lin JY, Lin CY. Adjusting Thickness before Injection: A New Trend for Preparing Collagen-stimulating Fillers. Plastic and Reconstructive Surgery – Global Open. 2021;9(6):e3653.

Bravo BSF, Calvacante T, Nobre CS, Bravo LG, Zafra MC, Elias MC. Exploring the Safety and Satisfaction of Patients Injected With Collagen Biostimulators-A Prospective Investigation Into Injectable Poly-l-Lactic Acid (PLLA). Journal of cosmetic dermatology. 2025;24(2):e16723.

NAKA, C. H. .; RAMOS, S. L.; OLIVEIRA, L. K. .; WARNAVIN, S. V. S. C. . Collagen bio-stimulators in facial rejuvenation: A literature review. Research, Society and Development, [S. l.], v. 13, n. 10, p. e72131047095, 2024. DOI: 10.33448/rsd-v13i10.47095.