Best Biostimulator for Face: Comparing Brands, Benefits, and Results

Biostimulators are the new generation of injectable skincare solutions, and both medical professionals and potential users are eager to learn more about them. That is why we prepared an article that explains the mechanics of biostimulators, as well as the most popular brands on the market, their benefits, and actual results. 

What Are Biostimulators?

Biostimulators are skincare injectables that stimulate the body’s natural production of elastin and collagen. Through this type of stimulation, the skin becomes stronger, smoother, and more flexible. Additionally, biostimulators are used to enhance the quality and the texture of the skin to create a more youthful appearance over time. 

The Difference Between Biostimulators and Traditional Fillers

The key goal of biostimulators is to provide skin tightening and hydration with minimal changes in volume, while traditional dermal fillers offer significant volume and structural changes. This is particularly important for more mature patients already hold excess volume in key areas like jawline and lower face, so they are looking for solutions that can tighten their skin. 

The Top Biostimulator Brands

The best biostimulator treatment brands to consider are: 

Nucleofill

Nucleofill is an innovative biostimulator based on polynucleotides, designed to deeply revitalise the skin and promote cellular renewal. This treatment works by stimulating fibroblasts to increase the production of collagen and elastin, while also improving tissue oxygenation and hydration. Nucleofill strengthens the skin’s extracellular matrix and provides a lifting effect without adding volume. It is ideal for patients looking to improve skin firmness, reduce oxidative stress, and achieve an overall rejuvenated look. Nuclefill helps improve the early signs of ageing, fight fine lines and loss of elasticity, and enhance tired or dull complexion. 

Sculptra

Sculptra is another well-known brand, and the products are made using poly-L-lactic acid (PLLA). The treatment has proven results in the stimulation of collagen production, addressing volume loss, wrinkle reduction, and improving skin quality. Sculptra brings gradual results over 3 to 6 months, promoting natural hydration and tissue regeneration. It is ideal for mature patients who look for enhanced skin texture and facial harmony that can last up to 25 months. 

Sculptra is a treatment suitable for: 

• Sunken under-eyes and eye bags
• Acne scars
• Droopy cheeks
• Nasolabial folds and marionette lines
• Strengthening and defining the jawline
• Buttocks lift

Radiesse

Radiesse is a dual-action biostimulatory filler that is widely used by patients who show signs of skin ageing. At first, it provides instant volumisation with the help of carboxymethylcellulose (CMC) which is used to combat the loss of volume. While CMC is being absorbed, calcium hydroxylapatite (CaHa) starts working on the stimulation of collagen production to provide sustained skin rejuvenation. Radiesse is an injectable treatment suitable both for facial correction and hand augmentation. As for the age, it is ideal for mature patients. It can be used on its own or combined with other biostimulators. All in all, it provides effective skin lifting and firming, addresses deep wrinkles, improves skin volume, and ensures lasting results. 

Lanluma

Lanluma is a collagen-stimulating injectable treatment made with poly-L-lactic acid (PLLA), but with formulations optimised for body contouring as well as facial rejuvenation. It works by activating the body’s natural collagen production, gradually improving volume, skin texture, and definition. Lanluma provides long-lasting, natural-looking results that develop over time, making it a popular choice for patients seeking subtle yet effective enhancements. It is especially beneficial for larger treatment areas and is often used for non-surgical body sculpting.

Lanluma is suitable for: 

• Body contouring and hip dips
• Facial volume loss
• Skin laxity in thighs, arms, and decolletage
• Smoothing of cellulite-prone areas
• Non-surgical buttocks augmentations
• Nasolabial folds and lower face rejuvenation

The Key Ingredients Used In Biostimulators 

All biostimulators contain at least one of the following ingredients:

PLLA

Poly-L-lactic acid or PLLA is a synthetic, biodegradable polymer that can stimulate the production of collagen over several months when injected. 

CaHa

Calcium hydroxyapatite or CaHa is a mineral that is naturally found in human bones and teeth. In aesthetic medicine, it is used as a dermal filler in the form of tiny particles suspended in a gel. CaHa also stimulates collagen production and provides instant volume. 

Polynucleotides

Polynucleotides have powerful regenerative properties, and when injected into the skin, they activate fibroblasts, promote tissue repair, and enhance the synthesis of collagen and elastin. They also improve hydration, restore skin elasticity, ans reduce inflammation. 

Treatment Protocols

Biostimulatory injectables are pretty quick, as they take less than a few minutes to perform. Depending on the type of injectable and the location, the aesthetician should use either a needle or a cannula. 

When Can You See the Results?

Since biostimulatotors literally stimulate the production of collagen, it is a process that takes time. Therefore, even if you pick a treatment that offers some initial volume, the full effects will develop gradually. To be more exact, the results begin to show after a few weeks, and they reach their peak after several months. This, for instance, is the major difference between skin booster vs biostimulator treatments.

What Is the Longevity of the Results?

The effects of biostimulators can last from just a few months to several years, depending on the product used, as well as individual factors like the patient’s skin type, age, and lifestyle. 

What Are the Potential Side Effects of Biostimulators?

Fortunately, these treatments rarely cause serious responses, and this also refers to biostimulation face side effects, but there are some types of reactions that might occur: 

• Redness
• Swelling
• Nodules and bumps
• Allergies
• Post-inflammatory pigmentation

Who Is the Ideal Candidate for the Treatment?

The natural production of collagen reaches its peak at the age of twenty, and after that, it breaks down at 1 to 1.5% per year. That is why patients in their late 20s and onwards can already benefit from biostimulators.

Conclusion

Biostimulators for facial treatments are among the most popular solutions out there, and medical practitioners who decide to buy biostimulators will improve their offerings in multiple ways. This article has already provided an overview of the top brands used in the industry, as well as additional details related to the use of the treatments, their benefits and potential side effects.

References: 

1. Fisher SM, Borab Z, Weir D, Rohrich RJ. The emerging role of biostimulators as an adjunct in facial rejuvenation: A systematic review. Journal of Plastic Reconstructive & Aesthetic Surgery. 2024;92:118-129.
2. Niamh Corduff. Surgical or Nonsurgical Facial Rejuvenation: The Patients’ Choice. Plastic and reconstructive surgery Global open. 2023;11(10):e5318-e5318.