What is Radiesse? Composition, Uses, and Why It Stands Out

Radiesse is more than just a popular dermal filler range – it’s a biostimulatory treatment that enhances facial volume while promoting the body’s natural collagen production. In this article, we’ll answer questions like What is Radiesse? and explore its unique formulation, key benefits, clinical uses, and product types. If you’re considering offering Radiesse in your clinic or curious about how it compares to other injectables, keep reading.

What Is Radiesse Dermal Filler & How Does It Work?

Radiesse is an FDA-approved injectable dermal filler manufactured by Merz Aesthetics. Unlike most hyaluronic acid-based dermal fillers featured on the market today, the Radiesse formula is composed of 25% calcium hydroxylapatite (CaHA) microspheres and a 75% carboxymethylcellulose gel carrier, offering a dual-phase effect:

• Instant lift – The gel matrix provides an immediate lift and volumizing effect in areas with volume loss.
• Collagen production – Over time, the CaHA particles stimulate neocollagenesis, the body’s natural collagen synthesis process, leading to long-lasting structural support and skin rejuvenation.

This distinct combination makes Radiesse filler an ideal product choice for patients seeking both facial contouring and improved skin quality over time.

Radiesse Dermal Filler Range

The Radiesse by Merz dermal filler line offers injectables tailored to various patient needs and treatment goals. Available Radiesse formulations on Best Buy Fillers:

• Radiesse (+) with Lidocaine (1 x 1.5 ml) – Combines volumizing effects with local anesthetic lidocaine to improve patient comfort.
• Radiesse (1 x 1.5 ml) – The original formulation, ideal for patients sensitive to lidocaine.
• Radiesse (1 x 3 ml) – Designed for treating larger areas, like the hands or body.

Clinics looking to stock up on high-quality CaHA fillers can buy Radiesse online at Best Buy Fillers shop for reliable and effective treatment results.

What is Radiesse Best Used For?

Radiesse fillers are commonly used to restore volume, contour facial features, and rejuvenate aging skin. Common treatment areas include:

• Cheeks and Midface – Radiesse fillers are a popular choice for midface volume restoration, contouring the cheeks and creating a youthful lift.
• Nasolabial Folds and Marionette Lines – The specialized CaHA formula of Radiesse fillers improves the look of deep folds and wrinkles by creating collagen over time.
• Jawline and Chin – Use Radiesse to add definition and balance to the chin and jaw.
• Hands – Rejuvenates by restoring volume and hiding visible veins and tendons.
• Neck, Décolletage, and Arms – When hyperdiluted, Radiesse improves skin quality, tightness, and elasticity.

Although a powerful, highly effective treatment in most facial and body areas, Radiesse fillers are not suitable for sensitive areas like the lips or tear troughs.

How Long Does Radiesse Last?

Radiesse is widely praised for its exceptional longevity, setting it apart from many traditional dermal fillers. Most patients enjoy results that last between 12 to 18 months, thanks to both the initial volumizing effect and ongoing collagen production. 

In many cases, the biostimulatory benefits continue to enhance skin quality and firmness well beyond the initial treatment window. For a deep dive into durability by treatment area and patient type, explore our full article on how long do Radiesse fillers last.

What Makes Radiesse Different From Other Fillers?

While many dermal fillers simply add volume, Radiesse stands out by offering regenerative benefits. Key differentiators include:

• Biostimulatory Action – Radiesse not only fills but also firms by triggering collagen production.
• Longer-Lasting Results – Radiesse generally lasts 12 to 18 months, often longer than most HA-based fillers.
• Versatility – Suitable for both face and body, and can be used in its hyperdiluted form to improve skin tone and texture.

Another important Radiesse characteristic to mention is that it is non-reversible, meaning it cannot be dissolved with enzymes like hyaluronidase, unlike hyaluronic acid-based fillers. This makes proper technique and injector experience especially important to ensure safe, precise, and satisfying outcomes.

Radiesse vs Juvederm​

Radiesse and Juvederm are both popular dermal fillers, but they differ significantly in composition, longevity, and how they interact with the skin. Learn more about their differences below or explore the Juvederm dermal filler range here.

Feature	Radiesse	Juvederm
Formulation	Calcium hydroxylapatite (CaHA) microspheres	Hyaluronic acid (HA)
Longevity	12 to 18+ months	6 to 12 months
Onset of Results	Immediate volume + gradual improvement via collagen stimulation	Immediate volume and hydration
Reversibility	Not reversible	Reversible with hyaluronidase

Radiesse vs Sculptra

Radiesse and Sculptra are both biostimulatory fillers, but they differ in composition, treatment protocol, and how quickly results appear. This comparison highlights their key features to help clinicians choose the best option based on patient goals.

Feature	Radiesse	Sculptra
Formulation	Calcium hydroxylapatite (CaHA) microspheres	Poly-L-lactic acid (PLLA)
Longevity	12 to 18+ months	Up to 24 months
Onset of Results	Immediate volume + gradual improvement via collagen stimulation	Gradual results only (visible after several weeks/months)
Number of Treatments	1 session with optional touch-up	2-3 sessions spaced 4-6 weeks apart
Reversibility	Not reversible	Not reversible

Who Is a Good Candidate for Radiesse?

Radiesse is well-suited for individuals seeking both immediate volume and long-term skin improvement.

Ideal Candidates

• Adults with moderate to severe facial wrinkles or volume loss
• Patients interested in long-term rejuvenation rather than quick fixes
• Those looking for treatments with fewer maintenance sessions

Not Recommended For

• Areas with thin skin or high mobility, such as lips or tear troughs
• Patients requiring reversible filler options

Why Clinics and Patients Choose Radiesse

If you’re looking to expand your services and add biostimulatory treatments like Radiesse to your practice, there are many clinical and commercial advantages to consider:

• Radiesse is a smart choice for aesthetic practices due to its extended longevity and, with that, fewer touch-up sessions, leading to higher patient satisfaction. 
• The product’s versatility enables clinics to address a wider range of concerns with a single filler. 
• With fewer syringes needed per patient each year, Radiesse also delivers a strong return on investment. 

FAQs About Radiesse Treatment

Whether you’re looking to use Radiesse for facial or hand rejuvenation, it’s natural to have questions about what to expect. This FAQ section addresses the most common concerns about Radiesse treatment, from results and longevity to suitability and safety.

What is the difference between Radiesse and fillers?

Radiesse is a biostimulatory filler made of CaHA, while most other fillers use only hyaluronic acid. It not only fills but also stimulates collagen production.

How long does Radiesse last?

Typically, results last 12 to 18 months, sometimes longer, depending on the area and individual patient factors such as metabolism and lifestyle.

What is Radiesse best used for?

Radiesse is best used for facial contouring, wrinkle reduction, hand rejuvenation, and skin tightening (in hyperdiluted form).

Does Radiesse really build collagen?

Yes, the CaHA particles trigger natural collagen production over time.

Does Radiesse look natural?

Absolutely. The results appear gradually and integrate well with facial movements and skin texture.

What age group is Radiesse for?

Ideal for patients aged 35 and up who are experiencing moderate to advanced signs of aging.

Conclusion

So, what is Radiesse? It’s more than just a filler – it’s a collagen-building powerhouse that delivers immediate and lasting aesthetic improvements. Whether you’re a patient exploring long-term solutions or a clinic looking for a premium product line, Radiesse offers proven results with clinical depth. Buy Radiesse online today at Best Buy Fillers and experience the benefits of this industry-leading biostimulatory filler.

References

1. Loghem JV, Yutskovskaya YA. Calcium hydroxylapatite: over a decade of clinical experience. J Clin Aesthet Dermatol. 2015 https://pmc.ncbi.nlm.nih.gov/articles/PMC2544361/
2. Alexandrovna Y, Kogan E. Improved neocollagenesis after diluted CaHA in neck/décolletage. J Drugs Dermatol. 2017;16(1):68‑74 https://jddonline.com/articles/improved-neocollagenesis-and-skin-mechanical-properties-after-injection-of-diluted-calcium-hydroxyla-S1545961616P0068X
3. Amiri M, Meçani R, et al. Calcium hydroxylapatite (CaHA) and aesthetic outcomes: a systematic review. J Clin Med. 2024;13(6):1686 https://www.mdpi.com/2077-0383/13/6/1686