Nucleofill Skin Booster: The Next Level of Skin Hydration and Rejuvenation

Key Takeaways

• Nucleofill is a polynucleotide-based skin booster that stimulates skin regeneration at a cellular level, not just superficial hydration.
• Unlike hyaluronic acid (HA) boosters, Nucleofill triggers fibroblast activation, collagen production, and tissue repair.
• Ideal for improving skin elasticity, hydration, and texture, Nucleofill is suitable for the face, neck, hands, and under-eye area.
• Results typically appear within a few weeks, with protocols recommending 2–4 treatments spaced a few weeks apart.
• Medical aestheticians increasingly prefer Nucleofill for its long-term rejuvenation benefits and versatile use in non-surgical anti-aging protocols.

What Is Nucleofill and How Does It Work?

Nucleofill is a next-generation skin booster that takes a unique approach to skin rejuvenation. Rather than relying on hyaluronic acid (HA) to draw moisture into the skin temporarily, Nucleofill uses highly purified polynucleotides, fragments of DNA that serve as bioactive molecules capable of triggering cellular repair mechanisms.

This polynucleotide-based biostimulation activates fibroblasts, encouraging them to produce new collagen and elastin while improving tissue oxygenation. It also enhances the skin’s ability to retain water, boosting hydration from within without relying on HA’s water-binding effect.

Because it works deep within the dermis, Nucleofill improves skin structure and firmness over time, offering long-term rejuvenation, not just a surface-level glow.

Nucleofill vs. HA Skin Boosters: What Sets It Apart?

Most traditional skin boosters, like Profhilo or other HA-based injectables, primarily work through instant hydration, thanks to their ability to attract and retain water in the extracellular matrix. While this leads to a temporary plump and glow, the effects often wear off unless repeated frequently.

Nucleofill, on the other hand, provides true bio-revitalization. It not only enhances hydration but also supports tissue regeneration by:

• Activating fibroblasts for collagen and elastin production
• Improving microcirculation and oxygen delivery
• Protecting against free radical damage

This makes Nucleofill polynucleotide products an ideal choice for clients looking for preventive anti-aging care and long-lasting skin quality improvements, which we covered in our Nucleofill polynucleotide blog post. We have also wrote about the dilemma: Nucleofill or Profhilo, as the decision often comes down to short-term vs. long-term results; hydration vs. regeneration.

Benefits of Nucleofill Skin Booster

The transformative effects of Nucleofill are evident across several key skin parameters:

1. Improved Hydration

Through better water retention and skin barrier function, Nucleofill leaves skin visibly dewy and supple.

2. Increased Elasticity and Firmness

By encouraging the production of structural proteins like collagen and elastin, skin feels firmer and appears more youthful.

3. Smoother Skin Texture

Clients notice a refined texture and reduction in fine lines, especially in delicate areas like under the eyes.

4. Antioxidant and Anti-Inflammatory Effects

Nucleofill neutralizes free radicals and reduces chronic inflammation, both key contributors to aging.

5. Progressive, Long-Term Results

Unlike HA fillers, which offer immediate but short-lived results, Nucleofill builds healthier skin over time.

Who Is It For? Ideal Candidates and Treatment Areas

Nucleofill is suitable for a wide range of patients and can be tailored to various skin types and concerns. It’s especially effective for:

• Dull, dehydrated skin
• Early signs of aging (30s and up)
• Crepey or sagging skin on the neck or jawline
• Under-eye hollowness or fine lines
• Sun-damaged hands

Common treatment areas include:

• Full face (especially perioral and periorbital regions)
• Neck and décolletage
• Back of the hands
• Eye contour (using Nucleofill Soft Eyes)

Treatment Protocol: How Many Sessions and When to Expect Results

Medical aestheticians typically recommend a course of 2 to 4 treatments spaced 2 to 3 weeks apart. The number of sessions may vary depending on the patient’s age, skin condition, and the specific Nucleofill product used.

When Do Results Appear?

Clients often start to notice improved hydration and glow after the first or second session, with cumulative effects becoming more apparent over the next 4 to 6 weeks. Because the treatment works by stimulating cellular renewal, results are gradual and long-lasting, with many patients reporting visible improvements for 6–9 months post-treatment.

Why Medical Aestheticians Are Turning to Nucleofill

Nucleofill is quickly gaining popularity among advanced injectors for several reasons:

• Biostimulation over volumization: Perfect for patients not ready for fillers but looking for skin quality improvements.
• Excellent safety profile: Since it doesn’t add volume, there’s minimal risk of vascular occlusion or nodules.
• Complements other treatments: Works synergistically with microneedling, RF, lasers, and even HA fillers.
• For aesthetic practices seeking to offer results that go beyond surface-level beauty, Nucleofill Skin Booster is a smart, science-backed addition to their portfolio.

Interested in integrating it into your treatments? You can buy Nucleofill products and also buy polynucleotides online from Best Buy Fillers shop.

Frequently Asked Questions

What is the result of Nucleofill?

Nucleofill improves skin hydration, elasticity, firmness, and overall texture. It promotes long-term regeneration rather than temporary plumpness.

Is Nucleofill Strong a filler?

No, Nucleofill Strong is not a filler. It is a biostimulator that triggers tissue regeneration and collagen production, making it ideal for skin quality improvement, not volumization.

Where is Nucleofill injected?

Nucleofill injection points include the face, neck, hands, and under the eyes, depending on the formulation.

How many treatments of Nucleofill are enough?

Most patients need 2 to 4 treatments spaced 2–3 weeks apart. Maintenance sessions every 6 months help prolong results.

How long does it take for Nucleofill to work?

Results can begin to appear after the first few sessions, but optimal improvements are typically seen after 4 to 6 weeks as cellular regeneration progresses.

Conclusion

As the demand for regenerative aesthetic solutions continues to grow, Nucleofill Skin Booster stands out as a cutting-edge treatment that goes far beyond hydration. Its polynucleotide-powered formula works deep within the skin, making it a reliable option for medical aestheticians committed to long-term skin health and rejuvenation. Whether you’re treating early signs of aging or want to enhance your clients’ skin quality protocols, Nucleofill offers a new gold standard in skin biostimulation.

Sources

1. Borrelli, A., et al. Polynucleotides in Aesthetic Medicine: New Regenerative Options. J Cosmet Dermatol. 2021; 20(9):2701–2708. https://pmc.ncbi.nlm.nih.gov/articles/PMC11311621/  
2. Titcomb L. A literature review on polynucleotide efficacy on skin rejuvenation, and review of the regulatory status and guidelines around polynucleotides. Journal of Aesthetic Nursing. Published April 16, 2025. https://www.aestheticnursing.co.uk/content/clinical/a-literature-review-on-polynucleotide-efficacy-on-skin-rejuvenation-and-review-of-the-regulatory-status-and-guidelines-around-polynucleotides
3. Budker V.G., Godovikov A.A., Naumova L.P., Slepneva I.A. Interaction of polynucleotides with natural and model membranes. Nucleic Acids Res. 1980;8:2499–2515. doi: 10.1093/nar/8.11.2499 DOI