Top Biostimulator Brands for Skin Rejuvenation: A Complete Guide

The potential of biostimulators in aesthetic medicine is enormous, and both medical practitioners and patients are more and more aware of their benefits. This cutting-edge type of treatment works on a cellular level to improve skin radiance, but there are many options on the market, making it harder to pick the right one. This article presents the top biostimulator brands and other details about the treatment, making it easier to pick the solution that perfectly matches patient needs. 

What Exactly Are Biostimulators?

Biostimulatory injectables enhance the body’s natural collagen production. Collagen is known to be essential for youthful skin, and it is also a protein responsible for skin firmness, tightening, and elasticity. As we age, the natural production of collagen drops, which leads to the creation of fine lines and wrinkles, as well as a loss of facial volume. This is where biostimulators step in by stimulating the production of collagen and tissue regeneration over time, therefore giving the skin a more radiant look. 

The Science Behind Biostimulation

Traditional dermal fillers that are mainly composed of hyaluronic acid provide instant volume, but they require plenty of maintenance afterwards. On the contrary, biostimulators take skin improvement one step further by stimulating the renewal of collagen from within. They can also improve skin hydration and reduce pigmentation through the stimulation of the production of intrinsic hyaluronic acid. 

The Top Biostimulator Brands

If you are looking to buy biostimulators online, these are the brands you should focus on: 

Nucleofill

Nucleofill is an advanced brand that specialises in biostimulatory products designed to improve skin health and quality. Thanks to the unique blend of polynucleotides, Nucleofill products are able to protect, hydrate, and rejuvenate the skin, all through the promotion of cellular regeneration and the enhancement of antioxidant effects. This brand is ideal for the treatment of visible signs of ageing such as fine lines, wrinkles, and sagging skin, and it is considered the best biostimulator for face by many. Essentially, Nucleofill is a non-surgical solution for achieving a radiant and youthful complexion. The brand’s products also deliver natural-looking results. 

Sculptra

Sculptra has a reputation for being a revolutionary biostimulatory filler that stimulates collagen production and provides both lasting and natural-looking results. Unlike traditional fillers that offer immediate changes, Sculptra works gradually to reduce wrinkles and restore facial volume. In other words, it offers subtle but noticeable results over time. Sculptra is made of biocompatible and biodegradable materials that are safe and effective, and as such, it is perfect for patients looking for non-surgical solutions for ageing skin. 

Radiesse

Radiesse is one of the leading biostimulatory fillers on the market. It is known for its unique formulation which includes CaHa (calcium hydroxylapatite) microspheres that are suspended in a water-based gel. This effective composition boosts the body’s natural production of collagen, but it also provides immediate volume restoration and visible wrinkle reduction. The products are versatile and suitable for the treatment of different areas such as chin wrinkles, nasolabial folds, and marionette lines. Radiesse improves facial contours and the overall skin structure, and the results can be noticeable up to 12 to 18 months. 

Lanluma

Lanluma is a cutting-edge biostimulatory filler designed to restore volume and stimulate collagen production, offering long-lasting improvements in skin texture and firmness. It uses PLLA (poly-L-lactic acid) as its active ingredient, which works beneath the skin to gradually boost collagen levels over time. Known for delivering subtle and natural-looking enhancements, Lanluma is particularly effective for treating volume loss in the face, neck, and even body areas such as the buttocks. The results are progressive, making it an excellent option for patients seeking gradual yet transformative rejuvenation.

Plenhyage

Plenhyage is a next-generation biostimulator that uses polymerised polynucleotides to support skin regeneration and improve tissue quality from within. The product works by activating fibroblasts and encouraging collagen synthesis, making it ideal for patients with signs of ageing, acne scars, or skin laxity. Plenhyage also has strong antioxidant and anti-inflammatory properties, which makes it especially beneficial for delicate or compromised skin. It is suitable for use on the face, neck, décolletage, and other sensitive areas where rejuvenation is needed without adding volume.

Ejal 40

Ejal 40 is also one of the leading brands in skin rejuvenation, and it offers biostimulator treatments designed to enhance the quality and density of the skin. The product uses a smart combination of hyaluronic acid and succinic acid, and thanks to that, it stimulates cellular regeneration, and the production of collagen and elastin. This advanced formula helps minimise wrinkles, sagging, and visible signs of photo ageing. It is suitable for various areas, including the face, hands, and neck. 

The Main Ingredients Used in Biostimulators

Here are the top ingredients found in the best biostimulator products on the market:

Polynucleotides

Polynucleotides are natural molecules derived from DNA fragments, known for their ability to deeply regenerate the skin. They work by stimulating cellular repair, improving tissue hydration, and activating fibroblasts to boost collagen production. Thanks to their biocompatibility and antioxidant properties, polynucleotides are ideal for improving skin elasticity, tone, and texture with minimal risk of adverse reactions.

PLLA

Poly-L-lactic acid (PLLA) is a synthetic, biodegradable substance that stimulates collagen production over time. Once injected, PLLA particles trigger a mild inflammatory response that activates fibroblasts and leads to gradual volume restoration and skin tightening. Products based on PLLA are best suited for patients who want subtle, progressive, and long-lasting improvements in facial contours and skin quality.

CaHa

Calcium hydroxylapatite (CaHa) consists of microscopic calcium particles suspended in a gel carrier. It provides immediate volume while also encouraging the long-term production of collagen. CaHa is commonly used in areas like the cheeks, jawline, and nasolabial folds to enhance definition and reduce wrinkles. This ingredient offers a natural look and feel, with results that can last up to 18 months or more.

The Key Benefits of Biostimulators

Biostimulators are known to:

Stimulate the Production of Collagen

Biostimulators kickstart the natural production of collagen in the body. By doing so, they improve skin texture, elasticity, and firmness. 

Reduce Fine Lines and Wrinkles

As people age, they lose facial volume, which leads to a sunken or hollow appearance. Biostimulatory fillers help the volume over time, resulting in a fuller and more youthful look. 

Improve Elasticity

Skin elasticity is its ability to stretch and bounce back, and this is exactly where biostimulators kick in. Through the promotion of collagen production, they create quicker regenerative processes that enhance skin elasticity. 

Provide Lasting Results

Traditional fillers provide temporary results, but this is not the case with biostimulators which bring long-lasting improvements to the skin. With proper administration and maintenance, patients can enjoy the results of biostimulatory injections for months and even years. 

Who Is the Ideal Patient for Biostimulators?

The ideal candidate for biostimulator treatments is typically someone experiencing early to moderate signs of ageing, such as fine lines, loss of skin elasticity, and mild volume depletion. Those are usually individuals who seek gradual, natural-looking results rather than immediate changes. Ideal patients are also those who are willing to follow a consistent treatment plan and aftercare instructions, understanding that results develop over time as collagen production is stimulated. People with realistic expectations, no active skin infections, and no history of severe allergies or autoimmune conditions are considered the best fit for biostimulatory injectables. 

Conclusion 

Biostimulators are some of the most innovative aesthetic treatments out there, and medical professionals keep showing interest in their use. However, with so many brands available on the market, trying to pick the right one can easily become overwhelming. That is why we prepared this article that can help both aestheticians and patients understand the basics of all the top biostimulator brands. 

References:

1. Cunha MG da, Engracia M, Souza LG de, Machado Filho CD. Biostimulators and their mechanisms of action. Surgical & Cosmetic Dermatology. 2020;12(2).
2. Fisher SM, Borab Z, Weir D, Rohrich RJ. The emerging role of biostimulators as an adjunct in facial rejuvenation: A systematic review. Journal of Plastic Reconstructive & Aesthetic Surgery. 2024;92:118-129.